Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752586 | 0.93 | ALDH1A1 (0.53) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL29954905 | 0.93 | ALDH1A1 (0.53) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL20344213 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL316047 | 0.80 | ALDH1A1 (0.60) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL8264566 | 0.77 | ALDH1A1 (0.56) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL31735654 | 0.74 | ALDH1A1 (0.53) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL2947016 | 0.74 | ALDH1A1 (0.53) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL13041691 | 0.73 | ALDH1A1 (0.59) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL12020717 | 0.73 | ALDH1A1 (0.56) | ALDH1A1TDP1HSP90AA1ESR2MAPT | |
| SCHEMBL4230805 | 0.72 | ALDH1A1 (0.56) | ALDH1A1TDP1HSP90AA1ESR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379234-B1 | HALOGENATED AMINOBENZOPHENONES AND AMINOBENZOYLPYRIDINES AS INHIBITORS OF IL-1 AND TNF | NOVARTIS AG (CH) | 2006-03-29 | — | — | EP | disclosed |
| US-6919336-B2 | Hallogenated aminobenzophenones and aminobenzoylpyridines as inhibitors of IL-1 and TNF | NOVARTIS AG (CH) | 2005-07-19 | — | — | US | disclosed |
| US-20040097731-A1 | Hallogenated aminobenzophenones and aminobenzoylpyridines as inhibitors of il-1and tnf | NOVARTIS AG (CH) | 2004-05-20 | — | — | US | disclosed |
| EP-1379234-A1 | HALOGENATED AMINOBENZOPHENONES AND AMINOBENZOYLPYRIDINES AS INHIBITORS OF IL-1 AND TNF | Novartis AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002076447-A1 | HALLOGENATED AMINOBENZOPHENONES AND AMINOBENZOYLPYRIDINES AS INHIBITORS OF IL-1 AND TNF | NOVARTIS AG (CH) | 2002-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097731-A1 | Hallogenated aminobenzophenones and aminobenzoylpyridines as inhibitors of il-1and tnf | TNF, NFKBIA, IL1A | ALDH1A1 299/4885TDP1 1429/4885HSP90AA1 1000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.