Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 4/20 | 0.35 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754220 | 0.73 | KIF11 (0.45) | ALDH1A1MEN1KMT2ALMNAKIF11 | |
| SCHEMBL6017115 | 0.70 | PDE4A (0.56) | ALDH1A1MEN1KMT2AMAPTTLR7 | |
| SCHEMBL5755195 | 0.70 | KIF11 (0.50) | ALDH1A1MEN1KMT2ALMNAKIF11 | |
| SCHEMBL5755785 | 0.68 | LMNA (0.41) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL5753789 | 0.67 | KIF11 (0.44) | KIF11KIF23 | |
| SCHEMBL5755201 | 0.66 | KIF11 (0.40) | ALDH1A1KIF11TSHRCASR | |
| SCHEMBL5756160 | 0.66 | KIF11 (0.43) | ALDH1A1LMNAKIF11GAA | |
| SCHEMBL5754399 | 0.66 | KIF11 (0.40) | ALDH1A1LMNAKIF11SMN1; SMN2HTT | |
| SCHEMBL5756034 | 0.66 | KDM4E (0.37) | ALDH1A1MAPTTLR7LMNASMN1; SMN2 | |
| SCHEMBL5755734 | 0.65 | PDE10A (0.40) | ALDH1A1MEN1KMT2AKIF11HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503993-A4 | COMPOUNDS, METHODS AND COMPOSITIONS | CYTOKINETICS INC (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1503993-A2 | COMPOUNDS, METHODS AND COMPOSITIONS | Cytokinetics, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003094839-A2 | PYRIMIDINONE COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |