Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.79 |
| ▸ | RAB9A | P51151 | 6/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312655 | 0.88 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTGAA | |
| SCHEMBL4275017 | 0.88 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL17822187 | 0.86 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2MAPTTAAR1 | |
| SCHEMBL1264805 | 0.84 | NPC1 (0.56) | NPC1RAB9AMAPTALDH1A1GAA | |
| SCHEMBL7274134 | 0.83 | NPC1 (0.85) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL11760394 | 0.82 | POLB (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL8324748 | 0.82 | TAS1R3 (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL15741668 | 0.82 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2MAPTTAAR1 | |
| SCHEMBL13175583 | 0.82 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2MAPTTAAR1 | |
| SCHEMBL4274970 | 0.82 | SMN1; SMN2 (0.60) | NPC1RAB9ASMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1659881-A2 | NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF | Senomyx Inc. (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005041684-A2 | NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF | SENOMYX INC. (US) | 2005-05-12 | — | — | WO | disclosed |