Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.64 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CCR3 | P51677 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11760394 | 0.88 | POLB (0.69) | TAS1R3TAS1R1HPGDCCR3POLB | |
| SCHEMBL930908 | 0.86 | ROCK2 (0.76) | ROCK2TP53POLBGAANPC1 | |
| SCHEMBL17758484 | 0.84 | ROCK2 (0.61) | ROCK2HPGDTP53POLBGAA | |
| SCHEMBL14340547 | 0.84 | TAS1R3 (0.64) | TAS1R3TAS1R1ROCK2TP53POLB | |
| SCHEMBL13753103 | 0.83 | HPGD (0.73) | HPGDPOLBLMNANPC1RAB9A | |
| SCHEMBL5753081 | 0.82 | NPC1 (0.79) | ROCK2GAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8324517 | 0.82 | TAS1R3 (0.65) | TAS1R3TAS1R1ROCK2TP53POLB | |
| SCHEMBL6580514 | 0.81 | ALDH1A1 (0.63) | TAS1R3TAS1R1HPGDTP53GAA | |
| SCHEMBL24073706 | 0.81 | ROCK2 (0.58) | ROCK2HPGDTP53POLBGAA | |
| SCHEMBL30892214 | 0.81 | POLB (0.68) | ROCK2HPGDTP53POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |