Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5636589 | 0.90 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL27517385 | 0.89 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL5755520 | 0.87 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPLA2G2A | |
| SCHEMBL5755707 | 0.86 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6762983 | 0.86 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPLA2G2A | |
| SCHEMBL5753275 | 0.84 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL5559262 | 0.83 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL5753323 | 0.82 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5750760 | 0.80 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL5754299 | 0.78 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615911-A1 | 5-HYDROXYINDOLES WITH N-OXIDE GROUPS AND USE THEREOF AS A PHOSPHODIESTERASE 4 INHIBITOR | Elbion AG (DE) | 2006-01-18 | — | — | EP | claimed |
| US-20040266760-A1 | 5-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | ELBION AG (DE) | 2004-12-30 | — | — | US | claimed |
| WO-2004094406-A1 | 5-HYDROXYINDOLES WITH N-OXIDE GROUPS AND USE THEREOF AS A PHOSPHODIESTERASE 4 INHIBITOR | ELBION AG (DE) | 2004-11-04 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266760-A1 | 5-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents | HTR5A, HTR4, HNMT | PDE4A 6/4885PDE4B 4/4885PDE4C 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.