Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5753175 | 0.90 | ALOX5 (0.35) | ALOX5HTTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5753653 | 0.90 | MC4R (0.36) | HTTSMN1; SMN2ALDH1A1MC4RDRD2 | |
| SCHEMBL5754551 | 0.87 | KDM4E (0.40) | ALOX5HTTSMN1; SMN2ALDH1A1MC4R | |
| SCHEMBL2866237 | 0.87 | SLC2A1 (0.43) | ALOX5HTTALDH1A1HPGDDRD2 | |
| Hydrochloric Acid SCHEMBL5754019 | 0.86 | SLC2A1 (0.44) | ALOX5HTTALDH1A1HPGDDRD2 | |
| SCHEMBL5753293 | 0.86 | USP2 (0.41) | ALOX5HTTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5753790 | 0.86 | ALDH1A1 (0.35) | ALOX5HTTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5754629 | 0.86 | ALDH1A1 (0.41) | ALOX5HTTSMN1; SMN2ALDH1A1MC4R | |
| SCHEMBL5753356 | 0.85 | HTR1A (0.36) | HTTSMN1; SMN2ALDH1A1MC4RDRD2 | |
| SCHEMBL5751143 | 0.84 | ALDH1A1 (0.38) | ALOX5HTTSMN1; SMN2ALDH1A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1099692-B1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2006-05-03 | — | — | EP | claimed |
| US-6737425-B1 | SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS | EISAI CO., LTD. (JP) | 2004-05-18 | — | — | US | claimed |
| EP-1099692-A1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-05-16 | — | — | EP | claimed |
| EP-1099692-B1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6737425-B1 | SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS | EISAI CO., LTD. (JP) | 2004-05-18 | — | — | US | disclosed |
| EP-1099692-A1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-05-16 | — | — | EP | disclosed |