Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 3/20 | 0.42 |
| ▸ | TRPC7 | Q9HCX4 | 3/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752224 | 0.89 | TRPC3 (0.43) | TRPC3TRPC7TRPV4CETPJAK2 | |
| SCHEMBL7529385 | 0.88 | MAPK13 (0.48) | TRPC3TRPC7TRPV4CETPJAK2 | |
| SCHEMBL5755616 | 0.87 | TRPC3 (0.40) | TRPC3TRPC7TRPV4CETPJAK2 | |
| SCHEMBL7468591 | 0.86 | TRPC3 (0.42) | TRPC3TRPC7TRPV4CETPJAK2 | |
| SCHEMBL5785137 | 0.86 | MAPK14 (0.54) | TRPC3TRPC7MAPK14MAPK13MAPK12 | |
| SCHEMBL6170576 | 0.84 | MAPK14 (0.49) | TRPC3TRPC7TRPV4F2RFAAH | |
| SCHEMBL6172304 | 0.84 | MAPK14 (0.49) | TRPC3TRPC7TRPV4CETPJAK2 | |
| SCHEMBL6173126 | 0.84 | MAPK14 (0.41) | TRPC3TRPC7TRPV4CETPJAK2 | |
| SCHEMBL6175245 | 0.82 | MAPK13 (0.49) | TRPC3TRPC7TRPV4CETPJAK2 | |
| SCHEMBL7455444 | 0.78 | TRPV4 (0.40) | TRPC3TRPC7TRPV4CETPJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628665-A2 | 3-PHENYL-4-(PYRIMIDIN-2-YL)-6-(PIPERIDIN-4-YL) DERIVATIVES AND RELATED COMPOUNDS AS TNF-ALPHA AND IL-1 INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-03-01 | — | — | EP | disclosed |
| US-20040254178-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2004-12-16 | — | — | US | disclosed |
| WO-2004094379-A2 | 3-PHENYL-4- (PYRIMIDIN-2-YL) -6- (PIPERIDIN-4-YL) DERIVATIVES AND RELATED COMPOUNDS AS TNF-ALPHA AND IL-1 INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254178-A1 | Substituted heterocyclic compounds and methods of use | MYLK2, MAPT, MUSK | TRPC3 3311/4885TRPC7 4797/4885TRPV4 3418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.