Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646583 | 0.79 | CA12 (0.48) | CA12CA1CA2CA9GPR119 | |
| SCHEMBL1862926 | 0.79 | CA12 (0.39) | CA12CA1CA2CA9GPR119 | |
| SCHEMBL1231703 | 0.79 | CA12 (0.39) | CA12CA1CA2CA9GPR119 | |
| SCHEMBL2378473 | 0.75 | CA12 (0.45) | CA12CA1CA2CA9GPR119 | |
| SCHEMBL15917112 | 0.73 | CA12 (0.33) | CA12CA1CA2CA9 | |
| SCHEMBL17362405 | 0.73 | PHGDH (0.32) | CA12CA1CA2CA9 | |
| SCHEMBL2372804 | 0.72 | CA12 (0.52) | CA12CA1CA2CA9 | |
| SCHEMBL27881190 | 0.72 | CA12 (0.52) | CA12CA1CA2CA9 | |
| SCHEMBL16321213 | 0.70 | GPR119 (0.48) | GPR119 | |
| SCHEMBL14937974 | 0.67 | CA12 (0.47) | CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699762-A1 | 5-AMINO-4-HYDROXY-7-(1H-INDOLMETHYL)-8-METHYLNONAMIDE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | Speedel Experimenta AG (CH) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005090305-A1 | 5-AMINO-4-HYDROXY-7-(1H-INDOLMETHYL)-8-METHYLNONAMIDE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | SPEEDEL EXPERIMENTA AG (CH) | 2005-09-29 | — | — | WO | disclosed |