Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893692 | 0.93 | ALPL (0.41) | CYP3A4ALPLALPITP53GAA | |
| SCHEMBL2895597 | 0.91 | CYP3A4 (0.49) | CYP3A4ALPLALPITP53GAA | |
| SCHEMBL2897581 | 0.84 | MAPK1 (0.40) | CYP3A4ALPLALPIGAAKMT2A | |
| SCHEMBL5485045 | 0.83 | DRD2 (0.34) | CYP3A4ALPLALPIKMT2AMEN1 | |
| SCHEMBL2895705 | 0.82 | CYP3A4 (0.52) | CYP3A4ALPLALPITP53GAA | |
| SCHEMBL2895698 | 0.82 | CHRNB2 (0.41) | CYP3A4ALPLALPIGAAKMT2A | |
| SCHEMBL2895530 | 0.80 | CYP3A4 (0.46) | CYP3A4ALPLALPIGAAKMT2A | |
| SCHEMBL5739564 | 0.79 | CYP3A4 (0.42) | CYP3A4ALPLALPIGAAKMT2A | |
| SCHEMBL2889757 | 0.79 | GRM5 (0.46) | GAAKMT2AMEN1RXFP1TSHR | |
| SCHEMBL2893164 | 0.77 | GAA (0.36) | CYP3A4ALPLALPIGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |