Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | EBP | Q15125 | 2/20 | 0.49 |
| ▸ | CCR3 | P51677 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | CCR1 | P32246 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431859 | 0.94 | CCR3 (0.54) | SIGMAR1EBPCCR3CHRM4CHRM3 | |
| SCHEMBL5240018 | 0.91 | RAB9A (0.52) | SIGMAR1EBPCCR3CHRM4CHRM3 | |
| SCHEMBL14431920 | 0.90 | RAB9A (0.58) | SIGMAR1EBPCCR3CHRM4CHRM3 | |
| SCHEMBL14431854 | 0.90 | SIGMAR1 (0.51) | SIGMAR1EBPCCR3CHRM4CHRM3 | |
| SCHEMBL5750440 | 0.88 | CCR3 (0.52) | SIGMAR1EBPCCR3CHRM4CHRM3 | |
| SCHEMBL5237846 | 0.86 | SIGMAR1 (0.60) | SIGMAR1EBPCCR3CHRM4CHRM3 | |
| SCHEMBL5239804 | 0.86 | KCNA3 (0.60) | SIGMAR1EBPCCR3CHRM4CHRM3 | |
| SCHEMBL5239794 | 0.86 | SIGMAR1 (0.60) | SIGMAR1EBPCCR3KCNA3 | |
| SCHEMBL14431875 | 0.86 | CCR3 (0.49) | SIGMAR1EBPCCR3CHRM4CHRM3 | |
| SCHEMBL5235995 | 0.86 | CHRM4 (0.54) | SIGMAR1EBPCCR3CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1099692-B1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2006-05-03 | — | — | EP | disclosed |
| US-6737425-B1 | SUCH AS 1-((4-CYANO-5-METHYL-4-PHENYL)HEXYL)-4-(2-(4-FLUORO -PHENOXY)ETHYL)PIPERAZINE; NERVE SELECTIVE CALCIUM ANTAGONISTS | EISAI CO., LTD. (JP) | 2004-05-18 | — | — | US | disclosed |
| EP-1099692-A1 | N,N-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-05-16 | — | — | EP | disclosed |