⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17627008 | 0.79 | KMT2A (0.47) | — | |
| SCHEMBL10189371 | 0.69 | MAPT (0.42) | — | |
| SCHEMBL6988140 | 0.68 | — | — | |
| SCHEMBL23291113 | 0.65 | MAPT (0.58) | — | |
| SCHEMBL23828872 | 0.64 | MAPT (0.53) | — | |
| SCHEMBL10853304 | 0.64 | ALDH1A1 (0.47) | — | |
| SCHEMBL12409044 | 0.63 | ALDH1A1 (0.50) | — | |
| SCHEMBL13757022 | 0.62 | MAPT (0.51) | — | |
| SCHEMBL2326678 | 0.61 | RAB9A (0.62) | — | |
| SCHEMBL14966908 | 0.60 | ATM (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303499-B1 | TETRAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-07-12 | — | — | EP | claimed |
| EP-1303499-A1 | TETRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | claimed |
| US-6399641-B1 | FOR THERAPY AND PROPHYLAXIS OF PSYCHOSIS, SCHIZOPHRENIA, ALZHEIMER'S DISEASE, COGNITIVE DISORDERS AND RESTRICTED BRAIN FUNCTION CAUSED BY BYPASS OPERATIONS OR TRANSPLANTS, POOR BLOOD SUPPLY TO THE BRAIN, SPINAL CORD INJURIES ETC. | HOFFMANN-LA ROCHE INC. | 2002-06-04 | — | — | US | claimed |
| US-20020022648-A1 | Novel 2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-02-21 | — | — | US | claimed |
| WO-2002006254-A1 | TETRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | claimed |
| CN-107118170-B | Preparation method of azoxytetrazole | 北京理工大学 | 2020-01-07 | — | — | CN | disclosed |
| EP-1303499-B1 | TETRAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-07-12 | — | — | EP | disclosed |
| CN-1214017-C | Tetrazole derivatives | HOFFMANN LA ROCHE (CH) | 2005-08-10 | — | — | CN | disclosed |
| CN-1441791-A | Tetrazole derivatives | HOFFMANN LA ROCHE (CH) | 2003-09-10 | — | — | CN | disclosed |
| EP-1303499-A1 | TETRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6399641-B1 | FOR THERAPY AND PROPHYLAXIS OF PSYCHOSIS, SCHIZOPHRENIA, ALZHEIMER'S DISEASE, COGNITIVE DISORDERS AND RESTRICTED BRAIN FUNCTION CAUSED BY BYPASS OPERATIONS OR TRANSPLANTS, POOR BLOOD SUPPLY TO THE BRAIN, SPINAL CORD INJURIES ETC. | HOFFMANN-LA ROCHE INC. | 2002-06-04 | — | — | US | disclosed |
| US-20020022648-A1 | Novel 2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists | HOFFMANN-LA ROCHE INC. | 2002-02-21 | — | — | US | disclosed |
| WO-2002006254-A1 | TETRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |