SCHEMBL5755545

SCHEMBL5755545

O=c1[nH]cc(-c2ccccc2)n1-c1cc(Cl)ccc1O

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.48
ALDH1A1 P00352 5/20 0.48
KDM4E B2RXH2 4/20 0.48
LMNA P02545 3/20 0.48
MAPT P10636 4/20 0.42
NPSR1 Q6W5P4 3/20 0.42
RXFP1 Q9HBX9 1/20 0.42
TP53 P04637 1/20 0.40
MAPK1 P28482 2/20 0.40
XBP1 P17861 1/20 0.40
GAA P10253 3/20 0.39
HSP90AA1 P07900 2/20 0.39
KCNMA1 Q12791 1/20 0.38
ALOX12 P18054 1/20 0.38
MEN1 O00255 3/20 0.37
KMT2A Q03164 3/20 0.37
ACLY P53396 2/20 0.37
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4053051 0.78 ALDH1A1 (0.60) HPGDALDH1A1KDM4ELMNAMAPT
SCHEMBL11126289 0.75 ALDH1A1 (0.69) HPGDALDH1A1KDM4ELMNAMAPT
SCHEMBL4232792 0.72 ALDH1A1 (0.65) HPGDALDH1A1KDM4ELMNAMAPT
SCHEMBL4059567 0.71 ALDH1A1 (0.52) HPGDALDH1A1KDM4ELMNAMAPT
SCHEMBL9119941 0.69 HSP90AA1 (0.75) KDM4ELMNAMAPTNPSR1TP53
SCHEMBL2035877 0.68 GAA (0.46) KDM4ELMNAMAPTNPSR1TP53
SCHEMBL11123802 0.66 MAPK1 (0.69) HPGDALDH1A1KDM4ELMNAMAPT
SCHEMBL11125616 0.66 ALDH1A1 (0.51) HPGDALDH1A1KDM4ELMNAMAPT
SCHEMBL5631019 0.66 HSP90AA1 (0.60) KDM4ELMNAMAPTNPSR1GAA
SCHEMBL9118474 0.64 MEN1 (0.53) KDM4ELMNAMAPTNPSR1HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6271249-B1 Diphenyl imidazoles as potassium channel modulators BRISTOL-MYERS SQUIBB COMPANY 2001-08-07 US claimed
EP-0915856-A4 DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS BRISTOL MYERS SQUIBB CO (US) 2006-04-12 EP disclosed
US-6271249-B1 Diphenyl imidazoles as potassium channel modulators BRISTOL-MYERS SQUIBB COMPANY 2001-08-07 US disclosed
US-6077861-A MODULATORS OF THE LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (BK) CHANNELS, THEREFORE, USEFUL IN THE TREATMENT OF ISCHEMIC STROKE BRISTOL-MYERS SQUIBB COMPANY (US) 2000-06-20 US disclosed
EP-0915856-A1 DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS Bristol-Myers Squibb Company (US) 1999-05-19 EP disclosed
US-5869509-A TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-02-09 US disclosed
WO-1998004135-A1 DIPHENYL HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-02-05 WO disclosed