Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 7/20 | 0.58 |
| ▸ | NTRK2 | Q16620 | 7/20 | 0.58 |
| ▸ | IGF1R | P08069 | 5/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11632467 | 0.81 | NTRK1 (0.50) | NTRK1NTRK2IGF1RFGFR1ALDH1A1 | |
| SCHEMBL5758129 | 0.79 | GNRHR (0.59) | NTRK1NTRK2IGF1RFGFR1 | |
| SCHEMBL5754581 | 0.76 | GNRHR (0.64) | — | |
| SCHEMBL8321111 | 0.74 | CYP1A2 (0.65) | NTRK1NTRK2IGF1RFGFR1CYP1A2 | |
| SCHEMBL21295403 | 0.74 | NTRK1 (1.00) | NTRK1NTRK2IGF1RFGFR1CYP1A2 | |
| SCHEMBL3030044 | 0.71 | CYP1A2 (0.64) | NTRK1NTRK2IGF1RFGFR1CYP1A2 | |
| SCHEMBL1260643 | 0.70 | KDM4E (0.51) | ALDH1A1HPGDHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL21295418 | 0.70 | NTRK1 (0.91) | NTRK1NTRK2IGF1RFGFR1CYP1A2 | |
| SCHEMBL30743937 | 0.70 | NTRK1 (0.91) | NTRK1NTRK2IGF1RFGFR1CYP1A2 | |
| SCHEMBL21295396 | 0.69 | NTRK1 (0.86) | NTRK1NTRK2IGF1RFGFR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412338-B1 | 1,3,5-TRIAZINE-2,4,6-TRIONES, PREPARATION AND USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20040162290-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. | 2004-08-19 | — | — | US | disclosed |
| EP-1412338-A1 | 1,3,5-TRIAZINE-2,4,6-TRIONES, PREPARATION AND USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | Neurocrine Biosciences, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| US-6677340-B2 | ADMINISTERING HEXAHYDRO-1,3-5-TRIAZINE-2,4,6-TRIONE DERIVATIVE AS ANTICARCINOGENIC AGENT; BENIGN PROSTATIC HYPERPLASIA, SLEEP DISORDER TREATMENT | NEUROCRINE BIOSCIENCES, INC. | 2004-01-13 | — | — | US | disclosed |
| US-20030130282-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2003-07-10 | — | — | US | disclosed |
| WO-2003011839-A1 | 1,3,5-TRIAZINE-2,4,6-TRIONES, PREPARATION AND USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130282-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | NTRK1 760/4885NTRK2 451/4885IGF1R 408/4885 |
| US-20040162290-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | NTRK1 760/4885NTRK2 451/4885IGF1R 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.