Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CCR1 | P32246 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
| ▸ | CCR8 | P51685 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1450328 | 0.80 | KDM4E (0.36) | HSP90AA1KDM4ELMNACCR1CCR5 | |
| SCHEMBL10402322 | 0.78 | HSP90AA1 (0.48) | GRM5HSP90AA1MAPK14MAPK11MAPK9 | |
| SCHEMBL30595872 | 0.78 | HSP90AA1 (0.52) | GRM5HSP90AA1MAPK14MAPK11MAPK9 | |
| SCHEMBL2814353 | 0.78 | HSP90AA1 (0.52) | GRM5HSP90AA1MAPK14MAPK11MAPK9 | |
| SCHEMBL2115044 | 0.77 | GRM5 (0.42) | GRM5HSP90AA1MAPK14MAPK11MAPK9 | |
| SCHEMBL1450322 | 0.77 | KDM4E (0.64) | GRM5HSP90AA1KDM4ELMNACCR1 | |
| SCHEMBL606773 | 0.75 | LMNA (0.42) | KDM4ELMNACYP1A2CYP2D6CYP3A4 | |
| SCHEMBL29394083 | 0.74 | KDM4E (0.67) | GRM5HSP90AA1MAPK14MAPK11MAPK9 | |
| SCHEMBL4294864 | 0.74 | KDM4E (0.67) | GRM5HSP90AA1MAPK14MAPK11MAPK9 | |
| SCHEMBL7502475 | 0.73 | HSP90AA1 (0.37) | GRM5HSP90AA1MAPK14MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664027-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005021532-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2005-03-10 | — | — | WO | claimed |