Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.52 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740939 | 0.95 | KIF11 (0.47) | KIF11KIF23TLR7GNRHRMC4R | |
| SCHEMBL4066353 | 0.92 | KIF11 (0.45) | KIF11KIF23GNRHRMC4R | |
| SCHEMBL5247152 | 0.90 | KIF11 (0.52) | KIF11KIF23MC4R | |
| SCHEMBL3961576 | 0.87 | KIF11 (0.57) | KIF11KIF23 | |
| SCHEMBL3905973 | 0.86 | KIF11 (0.51) | KIF11KIF23TLR7GNRHRMC4R | |
| SCHEMBL3958220 | 0.86 | KIF11 (0.63) | KIF11KIF23 | |
| SCHEMBL3957584 | 0.86 | KIF11 (0.57) | KIF11KIF23 | |
| SCHEMBL3966803 | 0.86 | KIF11 (0.68) | KIF11KIF23 | |
| SCHEMBL5740661 | 0.85 | TLR7 (0.43) | KIF11KIF23TLR7GNRHRSIGMAR1 | |
| SCHEMBL3872246 | 0.84 | KIF11 (0.74) | KIF11KIF23 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781674-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTION OF CANCER | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018628-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTI ON OF CANCER | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |