Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 9/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756237 | 1.00 | TDP1 (0.34) | TDP1FLT3KMT2AALDH1A1MAPT | |
| SCHEMBL5740679 | 0.82 | ALDH1A1 (0.40) | TDP1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL6689643 | 0.80 | ABCC1 (0.41) | TDP1KMT2AALDH1A1MAPTHPGD | |
| SCHEMBL5739313 | 0.80 | PDE4B (0.33) | RECQL | |
| SCHEMBL5739316 | 0.80 | PDE4B (0.33) | RECQL | |
| SCHEMBL5741511 | 0.78 | TNIK (0.39) | KMT2AALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL5741510 | 0.78 | TNIK (0.39) | KMT2AALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL5756239 | 0.78 | TNF (0.34) | TDP1FLT3KMT2AALDH1A1MAPT | |
| SCHEMBL5741304 | 0.74 | HSD17B10 (0.44) | FLT3KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL5738977 | 0.71 | ALDH1A1 (0.38) | KMT2AALDH1A1MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1152741-B1 | STABILIZED ANTIMICROBIAL SYSTEMS AND METHODS OF MAKING THE SAME | ETHICON INC (US) | 2006-10-25 | — | — | EP | claimed |
| EP-1406891-B1 | THIOCHROMENONES USED TO COMBAT PAINFUL CONDITIONS AND NEURODEGENERATIVE DISEASES | BAYER HEALTHCARE AG (DE) | 2006-03-22 | — | — | EP | disclosed |
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | HTT, HMOX1, SNCA | TDP1 115/4885FLT3 4564/4885KMT2A 3255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.