SCHEMBL5756478

SCHEMBL5756478

COc1ccc(CC(SCC2CCCCC2)C(CNC(=O)c2ccccc2O)NC(=O)C2NCCS2)cc1

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CACNA1B Q00975 2/20 0.34
ALDH1A1 P00352 2/20 0.33
P2RX7 Q99572 2/20 0.33
KMT2A Q03164 1/20 0.33
POLB P06746 2/20 0.32
HPGD P15428 3/20 0.32
MMP1 P03956 2/20 0.32
MMP2 P08253 1/20 0.32
MMP3 P08254 1/20 0.32
PSMB8 P28062 2/20 0.32
CTSS P25774 2/20 0.31
PNLIP P16233 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5757162 1.00 CACNA1B (0.34) CACNA1BALDH1A1P2RX7KMT2APOLB
SCHEMBL5753447 0.90 MEN1 (0.31) KMT2A
SCHEMBL5754943 0.90 MEN1 (0.31) KMT2A
SCHEMBL5753219 0.90 ALDH1A1 (0.34) CACNA1BALDH1A1P2RX7KMT2APOLB
SCHEMBL5756787 0.89 ALDH1A1 (0.34) CACNA1BALDH1A1P2RX7KMT2APOLB
SCHEMBL5755092 0.88 EPHX1 (0.32) ALDH1A1POLB
SCHEMBL5755757 0.87 KDM4E (0.41) CACNA1BALDH1A1P2RX7KMT2APOLB
SCHEMBL5752573 0.87 KDM4E (0.41) CACNA1BALDH1A1P2RX7KMT2APOLB
SCHEMBL5759242 0.87 KDM4E (0.41) CACNA1BALDH1A1P2RX7KMT2APOLB
SCHEMBL5754926 0.87 ALDH1A1 (0.43) CACNA1BALDH1A1P2RX7KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0997147-B1 AMINO ACID DERIVATIVES ONO PHARMACEUTICAL CO (JP) 2006-03-15 EP claimed