Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 20/20 | 0.75 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.75 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760551 | 0.90 | MMP1 (0.75) | MMP1ADAM17 | |
| SCHEMBL5758021 | 0.86 | MMP1 (1.00) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL5757881 | 0.86 | MMP1 (1.00) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL7507355 | 0.83 | MMP1 (0.81) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL5756703 | 0.83 | MMP1 (0.81) | MMP1ADAM17ADAMTS4TNFMMP2 | |
| SCHEMBL5760062 | 0.82 | MMP1 (0.53) | MMP1ADAM17 | |
| SCHEMBL5761544 | 0.81 | MMP1 (0.56) | MMP1ADAM17 | |
| SCHEMBL6239380 | 0.81 | MMP1 (0.58) | MMP1ADAM17MMP3MMP8MMP13 | |
| SCHEMBL5757615 | 0.80 | MMP1 (0.54) | MMP1ADAM17 | |
| SCHEMBL5760495 | 0.79 | ADAM17 (0.61) | MMP1ADAM17MMP3MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-B1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PROD INC (US) | 2006-05-10 | — | — | EP | claimed |