Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | ILK | Q13418 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5761323 | 0.93 | CYP3A4 (0.45) | EGFRKDM4ELMNASMN1; SMN2NPC1 | |
| SCHEMBL5756078 | 0.74 | KDM4E (0.55) | KDM4ENFKB1NFKB2RELALMNA | |
| SCHEMBL5757301 | 0.72 | KDM4E (0.48) | KDM4ENFKB1NFKB2RELALMNA | |
| SCHEMBL5757292 | 0.71 | KMT2A (0.48) | LMNASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL5758746 | 0.71 | MGAM (0.47) | KDM4ELMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5756311 | 0.70 | ROCK2 (0.45) | NFKB1NFKB2RELASMN1; SMN2NPC1 | |
| SCHEMBL5755215 | 0.64 | MAPK1 (0.52) | KDM4ELMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5757590 | 0.64 | CA2 (0.52) | KDM4ESMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL5759668 | 0.64 | KDM4E (0.51) | KDM4ENFKB1NFKB2RELALMNA | |
| SCHEMBL6104213 | 0.63 | GAA (0.44) | KDM4ENFKB1NFKB2RELALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539723-B1 | NOVEL USE OF BENZOTHIAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-05-24 | — | — | EP | claimed |