Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 5/20 | 0.77 |
| ▸ | GSK3B | P49841 | 12/20 | 0.68 |
| ▸ | PRKCG | P05129 | 11/20 | 0.68 |
| ▸ | PRKCB | P05771 | 11/20 | 0.68 |
| ▸ | PRKCA | P17252 | 11/20 | 0.68 |
| ▸ | PRKCD | Q05655 | 8/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.68 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.68 |
| ▸ | PRKACA | P17612 | 4/20 | 0.68 |
| ▸ | PRKACG | P22612 | 4/20 | 0.68 |
| ▸ | PRKACB | P22694 | 4/20 | 0.68 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.68 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.68 |
| ▸ | CDK4 | P11802 | 3/20 | 0.68 |
| ▸ | CCND1 | P24385 | 3/20 | 0.68 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.68 |
| ▸ | CDK2 | P24941 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.68 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758674 | 0.90 | CAMK2D (0.63) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL3784374 | 0.89 | PRKCA (0.76) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL5758796 | 0.88 | PRKCA (0.61) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL1993520 | 0.87 | PRKCA (0.64) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL1991771 | 0.86 | PRKCA (0.65) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL1996677 | 0.85 | GSK3B (0.61) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL3774309 | 0.84 | PRKCA (0.65) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL3775416 | 0.84 | GSK3B (0.79) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL1992099 | 0.83 | PRKCA (0.62) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL5758314 | 0.82 | CAMK2D (0.62) | CAMK2DGSK3BPRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |