Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.38 |
| ▸ | BID | P55957 | 4/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.37 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5693093 | 0.87 | CA12 (0.46) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6122758 | 0.85 | FOLH1 (0.42) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10491448 | 0.84 | GABRA1 (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL27860026 | 0.82 | ALDH1A1 (0.39) | CA12CA1CA2CA7CA9 | |
| SCHEMBL22746071 | 0.82 | DUSP3 (0.59) | CA12CA1CA2CA7CA9 | |
| SCHEMBL570378 | 0.80 | CA12 (0.52) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8384722 | 0.80 | FOLH1 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL22090410 | 0.79 | CA12 (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2866815 | 0.78 | ALDH1A1 (0.47) | ALDH1A1FEN1 | |
| SCHEMBL5693066 | 0.78 | L3MBTL1 (0.47) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664027-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005021532-A1 | SUBSTITUTED 2,3-DIHYDRO-1H-ISOINDOL-1-ONE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2005-03-10 | — | — | WO | disclosed |