Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.31 |
| ▸ | PDE4A | P27815 | 3/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758448 | 0.87 | PDE4B (0.40) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5758291 | 0.85 | PDE4B (0.34) | PDE4DPDE4BPDE4AGRM2 | |
| SCHEMBL5757580 | 0.83 | PDE4B (0.34) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5755717 | 0.79 | PDE4B (0.44) | DHFRPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5757544 | 0.78 | PDE4A (0.41) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1157280 | 0.77 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL5761415 | 0.76 | PDE4A (0.49) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL3610565 | 0.76 | PDE4D (0.50) | PDE4D | |
| SCHEMBL5756853 | 0.74 | AKT1 (0.36) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL3606207 | 0.74 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |