Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 15/20 | 0.84 |
| ▸ | PRKCB | P05771 | 14/20 | 0.84 |
| ▸ | GSK3B | P49841 | 13/20 | 0.84 |
| ▸ | PRKCG | P05129 | 11/20 | 0.84 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.48 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | PRKACG | P22612 | 3/20 | 0.48 |
| ▸ | PRKACB | P22694 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PRKCH | P24723 | 3/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3771589 | 0.97 | PRKCA (0.84) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5758306 | 0.92 | GSK3B (1.00) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5757844 | 0.86 | GSK3B (0.67) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL13013303 | 0.85 | PRKCA (0.63) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3775971 | 0.85 | GSK3B (0.61) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3771437 | 0.85 | PRKCA (0.84) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3783864 | 0.85 | PRKCA (0.80) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3779533 | 0.84 | PRKCA (0.64) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL5758690 | 0.83 | PRKCA (0.63) | PRKCAPRKCBGSK3BPRKCGPRKCD | |
| SCHEMBL3770811 | 0.82 | PRKCA (0.66) | PRKCAPRKCBGSK3BPRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |