SCHEMBL5759151

SCHEMBL5759151

c1ccc(COc2cccc(CCCCn3ccnc3)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HMOX1 P09601 1/20 0.64
CYP19A1 P11511 1/20 0.58
ALDH1A1 P00352 3/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
KDM4E B2RXH2 1/20 0.57
NPSR1 Q6W5P4 1/20 0.56
NOS1 P29475 1/20 0.56
HMOX2 P30519 1/20 0.56
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
TSHR P16473 1/20 0.55
CYP2C19 P33261 1/20 0.55
KMT2A Q03164 1/20 0.54
QPCT Q16769 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5760109 0.96 HMOX1 (0.65) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5757778 0.88 HMOX1 (0.83) HMOX1CYP19A1KMT2AQPCT
SCHEMBL5761107 0.84 HMOX1 (0.52) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5759785 0.84 HMOX1 (0.85) HMOX1CYP19A1KMT2AQPCT
3-(Benzyloxy)Aniline SCHEMBL8129778 0.81 MAOB (0.58) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL6030852 0.81 HMOX1 (0.71) HMOX1CYP19A1CYP1A2CYP3A4CYP2D6
SCHEMBL5759324 0.81 HMOX1 (0.53) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5758806 0.80 ATP4A (0.57) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5761475 0.80 ERBB2 (0.47) HMOX1ALDH1A1SMN1; SMN2KDM4ENPSR1
SCHEMBL5761481 0.80 ERBB2 (0.47) HMOX1ALDH1A1SMN1; SMN2KDM4ENPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1270571-B1 Heterocyclic compounds, their production and use TAKEDA PHARMACEUTICAL (JP) 2006-09-06 EP disclosed
EP-1270571-A1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-01-02 EP disclosed
CN-1349990-A Heterocyclic compound, its preparation and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-05-22 CN disclosed
CN-1077107-C Heterocyclic compounds, their preparation and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-01-02 CN disclosed
US-6211215-B1 AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US disclosed
CN-1223653-A Heterocyclic compounds, their preparation and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-07-21 CN disclosed