SCHEMBL5760109

SCHEMBL5760109

c1ccc(COc2cccc(CCCn3ccnc3)c2)cc1

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HMOX1 P09601 1/20 0.65
CYP19A1 P11511 1/20 0.60
ALDH1A1 P00352 3/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
KDM4E B2RXH2 1/20 0.58
KMT2A Q03164 1/20 0.55
QPCT Q16769 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
NOS1 P29475 1/20 0.54
HMOX2 P30519 1/20 0.54
TBXAS1 P24557 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
TSHR P16473 1/20 0.53
CYP2C19 P33261 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5759151 0.96 HMOX1 (0.64) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5759785 0.87 HMOX1 (0.85) HMOX1CYP19A1KMT2AQPCTTBXAS1
SCHEMBL5759324 0.84 HMOX1 (0.53) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5757778 0.84 HMOX1 (0.83) HMOX1CYP19A1KMT2AQPCTTBXAS1
SCHEMBL5758806 0.83 ATP4A (0.57) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5761300 0.82 PPARA (0.51) HMOX1ALDH1A1SMN1; SMN2KDM4ENPSR1
3-(Benzyloxy)Aniline SCHEMBL8129778 0.82 MAOB (0.58) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL5761107 0.81 HMOX1 (0.52) HMOX1CYP19A1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL3160306 0.81 CYP19A1 (0.71) HMOX1CYP19A1QPCTTBXAS1CYP1A2
SCHEMBL5758544 0.80 CYP1A2 (0.58) HMOX1KDM4EKMT2AQPCTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1270571-B1 Heterocyclic compounds, their production and use TAKEDA PHARMACEUTICAL (JP) 2006-09-06 EP disclosed
EP-1270571-A1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-01-02 EP disclosed
US-6211215-B1 AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US disclosed
EP-0912562-A1 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1999-05-06 EP disclosed
WO-1998003505-A2 HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-01-29 WO disclosed