Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | NPC1 | O15118 | 3/20 | 0.79 |
| ▸ | RAB9A | P51151 | 3/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | TP53 | P04637 | 3/20 | 0.79 |
| ▸ | MAPT | P10636 | 3/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.79 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.79 |
| ▸ | RELA | Q04206 | 1/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24041752 | 0.84 | LMNA (0.71) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL3235402 | 0.82 | NPC1 (0.72) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL6648239 | 0.82 | CYP19A1 (0.62) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL30632985 | 0.80 | ALDH1A1 (0.54) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL22398112 | 0.80 | ALDH1A1 (0.62) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL24041802 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL5758915 | 0.78 | ERBB2 (0.58) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL5758919 | 0.78 | ERBB2 (0.58) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL5758026 | 0.78 | ERBB2 (0.57) | SMN1; SMN2NPC1RAB9ALMNATP53 | |
| SCHEMBL5762705 | 0.78 | ERBB2 (0.57) | SMN1; SMN2NPC1RAB9ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1270571-B1 | Heterocyclic compounds, their production and use | TAKEDA PHARMACEUTICAL (JP) | 2006-09-06 | — | — | EP | disclosed |
| EP-1270571-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
| CN-1349990-A | Heterocyclic compound, its preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-05-22 | — | — | CN | disclosed |
| CN-1077107-C | Heterocyclic compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-02 | — | — | CN | disclosed |
| US-6211215-B1 | AROMATIC HETEROCYCLIC COMPOUND WITH AZOLE COMPOUND | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| CN-1223653-A | Heterocyclic compounds, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |