Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | FPR2 | P25090 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | MARS1 | P56192 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620293 | 0.84 | CNR1 (0.49) | CNR1HTTFPR2LMNASMN1; SMN2 | |
| SCHEMBL5764893 | 0.83 | CNR1 (0.47) | CNR1HTTFPR2LMNASMN1; SMN2 | |
| SCHEMBL5761293 | 0.82 | CNR1 (0.48) | CNR1HTTFPR2LMNASMN1; SMN2 | |
| SCHEMBL5763424 | 0.79 | KIT (0.33) | LMNASMN1; SMN2CASRKMT2A | |
| SCHEMBL5763777 | 0.79 | CYP3A4 (0.42) | CNR1MEN1MAPTKMT2A | |
| SCHEMBL5762210 | 0.79 | MAPT (0.35) | CNR1LMNACASRMEN1MAPT | |
| SCHEMBL5220710 | 0.79 | FPR1 (0.41) | CNR1FPR2SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL5220717 | 0.79 | FPR1 (0.41) | CNR1FPR2SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL5760995 | 0.78 | DRD2 (0.42) | HTTLMNASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL6621560 | 0.75 | CYP1A2 (0.43) | FPR2LMNASMN1; SMN2CASRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663966-A1 | 1,3-DISUBSTITUTED AZETIDINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | Novartis AG (CH) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026113-A1 | 1, 3-DISUBSTITUTED AZETIDINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISEASES | NOVARTIS AG (CH) | 2005-03-24 | — | — | WO | disclosed |