Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 2/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27702710 | 0.72 | SMYD3 (0.53) | FLT3SMYD3HTR4 | |
| Hydrochloric Acid SCHEMBL2355818 | 0.71 | SMYD3 (0.52) | FLT3SMYD3HTR4 | |
| SCHEMBL7127675 | 0.71 | CYP1A2 (0.45) | — | |
| SCHEMBL31269349 | 0.69 | HSD17B10 (0.33) | — | |
| SCHEMBL4436717 | 0.69 | HSD17B10 (0.33) | — | |
| SCHEMBL5758424 | 0.68 | GABRR1 (0.40) | HTR3A | |
| SCHEMBL6343838 | 0.68 | SMN1; SMN2 (0.50) | — | |
| SCHEMBL25211639 | 0.68 | ITGB3 (0.51) | PBKCHRM1SMYD3HTR4 | |
| SCHEMBL1721310 | 0.68 | GDA (0.39) | — | |
| SCHEMBL7771667 | 0.68 | SLC2A1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255764-B8 | PURINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | claimed |
| JP-2004508284-A | — | — | 2004-03-18 | — | — | JP | claimed |
| EP-1255764-A1 | PURINE DERIVATIVES | PFIZER INC. (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060835-A1 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-08-23 | — | — | WO | claimed |