Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | ENGASE | Q8NFI3 | 2/20 | 0.30 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.30 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760967 | 0.99 | MAPT (0.35) | MAPTNR3C1EGFRLMNASMN1; SMN2 | |
| SCHEMBL5760950 | 0.94 | MAPT (0.35) | MAPTEGFRLMNASMN1; SMN2WDR5 | |
| SCHEMBL5763457 | 0.91 | MAPT (0.40) | MAPTEGFRLMNAWDR5KMT2A | |
| SCHEMBL5763486 | 0.90 | MAPT (0.40) | MAPTEGFRLMNASMN1; SMN2WDR5 | |
| SCHEMBL5763465 | 0.88 | MAPT (0.40) | MAPTEGFRLMNASMN1; SMN2WDR5 | |
| SCHEMBL5761303 | 0.87 | MAPT (0.38) | MAPTEGFRLMNASMN1; SMN2WDR5 | |
| SCHEMBL5763751 | 0.86 | MAPT (0.37) | MAPTEGFRLMNAWDR5KMT2A | |
| SCHEMBL5763543 | 0.86 | HPGD (0.33) | MAPTEGFRALDH1A1HPGDPSEN1 | |
| SCHEMBL5763768 | 0.85 | MAPT (0.37) | MAPTEGFRLMNAWDR5KMT2A | |
| SCHEMBL5763795 | 0.83 | HPGD (0.33) | MAPTALDH1A1HPGDPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556371-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PRODRUGS OF PROTON PUMP INHIBITOR | WINSTON PHARMACEUTICALS LLC (US) | 2006-04-19 | — | — | EP | disclosed |
| US-20050182101-A1 | Prodrugs of proton pump inhibitors | GARST MICHAEL (US) | 2005-08-18 | — | — | US | disclosed |
| US-20050143423-A1 | Prodrugs of proton pump inhibitors background of the invention | GARST MICHAEL (US) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143423-A1 | Prodrugs of proton pump inhibitors background of the invention | ABCB11, SLC10A2, SI | MAPT 4128/4885NR3C1 2960/4885EGFR 2473/4885 |
| US-20050182101-A1 | Prodrugs of proton pump inhibitors | ABCB11, SLC10A2, SI | MAPT 4098/4885NR3C1 2738/4885EGFR 3480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.