Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | FPR1 | P21462 | 2/20 | 0.42 |
| ▸ | FPR2 | P25090 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763136 | 0.92 | MCHR1 (0.47) | MCHR1ROCK2CYP1A2 | |
| SCHEMBL5763921 | 0.89 | MCHR1 (0.50) | MCHR1ROCK2FPR1FPR2ALDH1A1 | |
| SCHEMBL5844743 | 0.84 | KMT2A (0.38) | MCHR1ROCK2CYP3A4CYP2D6MEN1 | |
| SCHEMBL5847052 | 0.84 | P2RY1 (0.40) | MCHR1ROCK2FPR2TSHRMEN1 | |
| SCHEMBL5846345 | 0.82 | EGLN1 (0.39) | MCHR1ROCK2 | |
| SCHEMBL5845894 | 0.82 | KDM4E (0.41) | ROCK2FPR1FPR2TSHRMEN1 | |
| SCHEMBL5762922 | 0.79 | MCHR1 (0.47) | MCHR1ROCK2CYP1A2 | |
| SCHEMBL5847025 | 0.79 | MCHR1 (0.48) | MCHR1ROCK2CYP1A2 | |
| SCHEMBL5757964 | 0.77 | MCHR1 (0.38) | MCHR1 | |
| SCHEMBL5846685 | 0.75 | ALDH1A1 (0.42) | MCHR1ALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101885-B2 | 1-(4-Bromo-phenyl)-3-[2-(4-methyl-piperazin-1-yl)-pyridin-3-yloxy]-pyrrolidin-2-one; antagonists of the serotonin 5HT1B receptor; treating depression | PFIZER INC (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1638932-A1 | NOVEL PIPERAZINYL-ARYLOXY AND PIPERAZINYL-HETEROARYLOXY-N-ARYL LACTAMS | Pfizer Products Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20040266781-A1 | Novel piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams | PFIZER INC | 2004-12-30 | — | — | US | disclosed |
| WO-2004110994-A1 | NOVEL PIPERAZINYL-ARYLOXY AND PIPERAZINYL-HETEROARYLOXY-N-ARYL LACTAMS | PFIZER PRODUCTS INC. (US) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266781-A1 | Novel piperazinyl-aryloxy and piperazinyl-heteroaryloxy-n-aryl lactams | OPRD1, HTR5A, PTGDR | MCHR1 646/4885ROCK2 3762/4885FPR1 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.