Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TERT | O14746 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766496 | 0.88 | ALDH1A1 (0.35) | MAPTTERTKDM4EHDAC3HDAC1 | |
| SCHEMBL5764891 | 0.84 | KDM4E (0.35) | MAPTTERTKDM4E | |
| SCHEMBL5766878 | 0.82 | CCNE2 (0.42) | MAPTKDM4E | |
| SCHEMBL5766199 | 0.81 | ALDH1A1 (0.42) | MAPTKDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL5766819 | 0.81 | KDM4E (0.35) | MAPTTERTKDM4E | |
| SCHEMBL5765490 | 0.80 | KDM4E (0.37) | MAPTKDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL5679654 | 0.79 | HDAC3 (0.35) | MAPTKDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL5766555 | 0.79 | HDAC1 (0.36) | MAPTKDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL5767116 | 0.79 | KDM4E (0.34) | MAPTKDM4E | |
| SCHEMBL3624678 | 0.78 | KDM4E (0.33) | MAPTTERTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |