Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.32 |
| ▸ | KDM6B | O15054 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | KDM4A | O75164 | 2/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774143 | 0.75 | HTT (0.40) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL847542 | 0.73 | ALDH1A1 (0.44) | TDP1SIRT3KDM4EALDH1A1GAA | |
| SCHEMBL3605168 | 0.73 | FFAR1 (0.34) | ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL4713935 | 0.71 | KDM4E (0.43) | TDP1KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL3403141 | 0.69 | PREP (0.43) | ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1651982 | 0.68 | LMNA (0.47) | TDP1ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4710599 | 0.67 | — | — | |
| SCHEMBL1652097 | 0.67 | HDAC1 (0.44) | KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL1885868 | 0.66 | TDP1 (0.52) | TDP1SIRT3KDM4CKDM6BKDM4E | |
| SCHEMBL30281300 | 0.66 | KDM4C (0.59) | TDP1SIRT3KDM4CKDM6BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725101-A1 | 2-PYRIDINYL [7-(SUBSTITUTED-PYRIDIN-4-YL) PYRAZOLO[1,5-A] PYRIMIDIN-3-YL] METHANONES | DOV Pharmaceutical Inc. (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005084439-A1 | 2-PYRIDINYL[7-(SUBSTITUTED-PYRIDIN-4-YL) PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]METHANONES | DOV PHARMACEUTICAL, INC. (US) | 2005-09-15 | — | — | WO | disclosed |