SCHEMBL847542

SCHEMBL847542

CN(C)CC(=C=O)c1cccnc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
APP P05067 1/20 0.44
GAA P10253 1/20 0.44
HCAR3 P49019 1/20 0.44
HCAR2 Q8TDS4 1/20 0.44
LMNA P02545 2/20 0.43
KDM4E B2RXH2 1/20 0.43
F7 P08709 1/20 0.43
F3 P13726 1/20 0.43
SARM1 Q6SZW1 1/20 0.43
SIRT2 Q8IXJ6 1/20 0.43
SIRT6 Q8N6T7 1/20 0.43
SIRT1 Q96EB6 1/20 0.43
SIRT3 Q9NTG7 1/20 0.43
SIRT5 Q9NXA8 1/20 0.43
SIRT4 Q9Y6E7 1/20 0.43
CYP1A2 P05177 2/20 0.43
CYP3A4 P08684 2/20 0.43
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5774143 0.80 HTT (0.40) ALDH1A1LMNAKDM4ECYP1A2CYP3A4
SCHEMBL289811 0.79 EGFR (0.50) ALDH1A1KDM4EHIF1AHTT
SCHEMBL722807 0.78 F7 (0.52) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL1652097 0.77 HDAC1 (0.44) ALDH1A1KDM4EALOX15
SCHEMBL1651065 0.75 ALDH1A1 (0.44) ALDH1A1KDM4E
Niacin SCHEMBL5066008 0.74 ALDH1A1 (0.68) ALDH1A1APPGAAHCAR3HCAR2
SCHEMBL1651952 0.73 POLB (0.46) HCAR2KDM4ECYP1A2CYP3A4ALOX15
SCHEMBL5763247 0.73 TDP1 (0.37) ALDH1A1GAAKDM4ESIRT3CYP1A2
SCHEMBL933985 0.73 NAPRT (0.46) ALDH1A1GAALMNA
SCHEMBL1651006 0.73 HCAR2 (0.46) ALDH1A1HCAR2LMNAKDM4ECHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105574346-A Design method and detection method for polypeptide conjugate and irreversible inhibitor CELGENE AVILOMICS RES INC 2016-05-11 CN disclosed
EP-2295424-B1 Processes for the preparation of novel phenylaminopyrimidine derivatives as inhibitors of BCR-ABL kinase NATCO PHARMA LTD (IN) 2015-10-14 EP disclosed
WO-2013035102-A1 PROCESSES FOR THE PREPARATION OF IMATINIB BASE AND INTERMEDIATES THEREOF NATCO PHARMA LIMITED (IN) 2013-03-14 WO disclosed
EP-2432775-A2 SUBSTANTIALLY PURE IMATINIB OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF Actavis Group PTC EHF (IS) 2012-03-28 EP disclosed
WO-2011095835-A1 HIGHLY PURE IMATINIB OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF ACTAVIS GROUP PTC EHF (IS) 2011-08-11 WO disclosed
EP-2352827-A1 ALGORITHM FOR DESIGNING IRREVERSIBLE INHIBITORS Avila Therapeutics, Inc. (US) 2011-08-10 EP disclosed
WO-2011049150-A1 PYRONE COMPOUND AND ITS USE FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-04-28 WO disclosed
WO-2011039782-A1 PROCESSES FOR PREPARING IMATINIB AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF IND-SWIFT LABORATORIES LIMITED (IN) 2011-04-07 WO disclosed
EP-2295424-A1 Processes for the preparation of novel phenylaminopyrimidine derivatives as inhibitors of BCR-ABL kinase Natco Pharma Limited (IN) 2011-03-16 EP disclosed
EP-2265599-A2 CRYSTAL FORM OF PHENYLAMINO PYRIMIDINE DERIVATIVE Natco Pharma Limited (IN) 2010-12-29 EP disclosed
WO-2006070198-A1 PYRAZOLE DERIVATIVES AS THAT MODULATE THE ACTIVITY OF CDK, GSK AND AURORA KINASES ASTEX THERAPEUTICS LIMITED (GB) 2006-07-06 WO disclosed
EP-1663953-A1 INHIBITORS OF HISTONE DEACETYLASE Methylgene, Inc. (CA) 2006-06-07 EP disclosed
EP-1648896-A1 7-SUBSTITUTED 3-NITRO-PYRAZOLO [1,5-A] PYRIMIDINES FERRER INTERNACIONAL, S.A. (ES) 2006-04-26 EP disclosed
WO-2005030705-A9 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE INC (CA) 2006-04-20 WO disclosed
WO-2006027795-A1 NOVEL PHENYLAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF BCR-ABL KINASE NATCO PHARMA LIMITED (IN) 2006-03-16 WO disclosed
EP-1590340-A1 INHIBITORS OF HISTONE DEACETYLASE Methylgene, Inc. (CA) 2005-11-02 EP disclosed
WO-2005030705-A1 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2005-04-07 WO disclosed
WO-2005030704-A1 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2005-04-07 WO disclosed
WO-2005014596-A1 7-SUBSTITUTED 3-NITRO-PYRAZOLO `1,5-A! PYRIMIDINES FERRER INTERNACIONAL, S.A. (ES) 2005-02-17 WO disclosed
WO-2004069823-A1 INHIBITORS OF HISTONE DEACETYLASE METHYLGENE, INC. (CA) 2004-08-19 WO disclosed