Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3607193 | 0.78 | ADRA2B (0.34) | L3MBTL1GABRA1GABRB2AURKADAPK3 | |
| SCHEMBL4859718 | 0.74 | AURKA (0.35) | GABRA1GABRB2AURKADAPK3MAP4K4 | |
| SCHEMBL7556444 | 0.70 | GABRA1 (0.48) | L3MBTL1GABRA1GABRB2AURKADAPK3 | |
| SCHEMBL22540442 | 0.69 | PADI4 (0.41) | L3MBTL1 | |
| SCHEMBL9559593 | 0.67 | MEN1 (0.31) | GABRA1GABRB2AURKADAPK3MAP4K4 | |
| SCHEMBL1021570 | 0.67 | AURKA (0.39) | L3MBTL1GABRA1GABRB2AURKADAPK3 | |
| SCHEMBL4000170 | 0.67 | GABRA1 (0.42) | L3MBTL1GABRA1GABRB2AURKADAPK3 | |
| SCHEMBL17924772 | 0.66 | GABRA1 (0.40) | L3MBTL1GABRA1GABRB2AURKADAPK3 | |
| SCHEMBL28758160 | 0.65 | DPP4 (0.52) | GABRA1GABRB2AURKADAPK3MAP4K4 | |
| SCHEMBL9559538 | 0.65 | GABRA1 (0.31) | GABRA1GABRB2AURKADAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620422-A2 | PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004099170-A2 | PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | disclosed |