Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764412 | 0.81 | MTNR1A (0.43) | MTNR1AMTNR1BGAA | |
| SCHEMBL30292430 | 0.81 | MTNR1A (0.53) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL5763858 | 0.78 | HPGD (0.47) | MTNR1AMTNR1BHPGDKDM4EHTT | |
| SCHEMBL984633 | 0.77 | SMN1; SMN2 (0.44) | NPC1RAB9AMTNR1AMTNR1BALDH1A1 | |
| Hydrochloric Acid SCHEMBL27661343 | 0.77 | MTNR1A (0.42) | MTNR1AMTNR1BHPGD | |
| SCHEMBL29226728 | 0.76 | MTNR1A (0.45) | NPC1RAB9AMTNR1AMTNR1BKDM4E | |
| SCHEMBL5401523 | 0.76 | PARP1 (0.50) | MTNR1AMTNR1BALDH1A1KDM4EGAA | |
| SCHEMBL8823672 | 0.76 | P2RX7 (0.49) | P2RX7 | |
| Hydrochloric Acid SCHEMBL9242534 | 0.76 | MTNR1B (0.42) | MTNR1AMTNR1B | |
| SCHEMBL26216592 | 0.75 | TDP1 (0.47) | NPC1RAB9AMTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651637-A1 | 3-AMINO CHROMAN AND 2-AMINO TETRALIN DERIVATIVES | Wyeth (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005012291-A1 | 3-AMINO CHOMAN AND 2-AMINO TETRALIN DERIVATIVES | WYETH (US) | 2005-02-10 | — | — | WO | disclosed |