Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 3/20 | 0.46 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 8/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764623 | 1.00 | NAAA (0.46) | NAAACALCRLXIAPCTSLALDH1A1 | |
| SCHEMBL1435407 | 0.83 | CALCRL (0.51) | NAAACALCRLALDH1A1ASAH1 | |
| SCHEMBL2893178 | 0.83 | CALCRL (0.51) | NAAACALCRLALDH1A1ASAH1 | |
| SCHEMBL5554408 | 0.83 | CALCRL (0.51) | NAAACALCRLALDH1A1ASAH1 | |
| SCHEMBL5762909 | 0.81 | XIAP (0.47) | XIAPALDH1A1 | |
| SCHEMBL5763039 | 0.81 | MASP2 (0.42) | XIAPALDH1A1 | |
| SCHEMBL5762197 | 0.81 | XIAP (0.47) | XIAPALDH1A1 | |
| SCHEMBL5761726 | 0.81 | MASP2 (0.42) | XIAPALDH1A1 | |
| SCHEMBL5764621 | 0.80 | KDM1A (0.50) | NAAACALCRLASAH1 | |
| SCHEMBL5763990 | 0.80 | KDM1A (0.50) | NAAACALCRLASAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |