Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | WDR5 | P61964 | 2/20 | 0.38 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.38 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.38 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.38 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.38 |
| ▸ | ATP4A | P20648 | 2/20 | 0.38 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.38 |
| ▸ | ATP4B | P51164 | 2/20 | 0.38 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.38 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.38 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14387723 | 0.95 | BRS3 (0.44) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| SCHEMBL5446485 | 0.94 | BRS3 (0.44) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| Lithium SCHEMBL5764061 | 0.94 | BRS3 (0.44) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| SCHEMBL5764045 | 0.94 | BRS3 (0.44) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| SCHEMBL13215288 | 0.87 | BRS3 (0.46) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| SCHEMBL5367609 | 0.87 | BRS3 (0.46) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| SCHEMBL7009207 | 0.86 | BRS3 (0.51) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| SCHEMBL5763533 | 0.84 | CYP2C9 (0.40) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| SCHEMBL14356254 | 0.84 | BRS3 (0.47) | BRS3CYP2C9ALDH1A1KMT2AMEN1 | |
| SCHEMBL5358479 | 0.82 | BRS3 (0.44) | BRS3CYP2C9ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556371-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PRODRUGS OF PROTON PUMP INHIBITOR | WINSTON PHARMACEUTICALS LLC (US) | 2006-04-19 | — | — | EP | disclosed |
| US-20050182101-A1 | Prodrugs of proton pump inhibitors | GARST MICHAEL (US) | 2005-08-18 | — | — | US | disclosed |
| US-20050143423-A1 | Prodrugs of proton pump inhibitors background of the invention | GARST MICHAEL (US) | 2005-06-30 | — | — | US | disclosed |
| US-6897227-B2 | Prodrugs of proton pump inhibitors | Winston Pharmaceuticals, Inc. (US) | 2005-05-24 | — | — | US | disclosed |
| US-20040102484-A1 | Prodrugs of proton pump inhibitors | ALEVIUM PHARMACEUTICALS, INC. | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102484-A1 | Prodrugs of proton pump inhibitors | ABCB11, SLC10A2, SI | BRS3 528/4885CYP2C9 92/4885ALDH1A1 397/4885 |
| US-20050143423-A1 | Prodrugs of proton pump inhibitors background of the invention | ABCB11, SLC10A2, SI | BRS3 556/4885CYP2C9 49/4885ALDH1A1 405/4885 |
| US-20050182101-A1 | Prodrugs of proton pump inhibitors | ABCB11, SLC10A2, SI | BRS3 541/4885CYP2C9 83/4885ALDH1A1 494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.