SCHEMBL5764637

SCHEMBL5764637

[c]1ccc(-c2ccccc2)c(-c2ccsc2)c1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 4/20 0.52
CYP2B6 P20813 3/20 0.52
CYP2E1 P05181 1/20 0.52
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
CDK8 P49336 1/20 0.38
ADORA1 P30542 2/20 0.37
ADORA2A P29274 2/20 0.37
MAOB P27338 1/20 0.36
PTPRC P08575 1/20 0.35
GLO1 Q04760 1/20 0.35
PRMT6 Q96LA8 1/20 0.34
GPR84 Q9NQS5 1/20 0.34
TDO2 P48775 1/20 0.33
FYN P06241 1/20 0.33
PDGFRB P09619 1/20 0.32
PDGFRA P16234 1/20 0.32
SLC6A9 P48067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL618853 0.83 BACE1 (0.39) CYP2A6CYP2B6
SCHEMBL7058734 0.81 CYP2A6 (0.70) CYP2A6CYP2B6CYP2E1CYP3A4CYP2C9
SCHEMBL27629739 0.79 ALDH1A1 (0.41) CYP2A6CYP3A4
SCHEMBL445102 0.79 ALDH1A1 (0.41) CYP2A6CYP3A4
SCHEMBL3870533 0.79 BACE1 (0.36) CYP2A6CYP2B6
SCHEMBL6880077 0.79 ALDH1A1 (0.41) CYP2A6CYP3A4
SCHEMBL6474583 0.79 BACE1 (0.36) CYP2A6CYP2B6
SCHEMBL27870289 0.79 CYP2A6 (0.67) CYP2A6CYP2B6CYP2E1CYP3A4CYP2C9
SCHEMBL9957984 0.77 NOTUM (0.52) ADORA1ADORA2A
SCHEMBL9958265 0.77 NOTUM (0.52) ADORA1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2006525329-A 2006-11-09 JP claimed
EP-1701954-A1 N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES Warner-Lambert Company LLC (US) 2006-09-20 EP claimed
EP-1620420-A2 SUBSTITUTED CARBOXYLIC ACIDS The Institutes for Pharmaceutical Discovery, LLC (US) 2006-02-01 EP claimed
WO-2005066165-A1 N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES WARNER-LAMBERT COMPANY LLC (US) 2005-07-21 WO claimed
WO-2004099168-A2 SUBSTITUTED CARBOXYLIC ACIDS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO claimed
EP-1620420-A2 SUBSTITUTED CARBOXYLIC ACIDS The Institutes for Pharmaceutical Discovery, LLC (US) 2006-02-01 EP disclosed
WO-2004099168-A2 SUBSTITUTED CARBOXYLIC ACIDS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO disclosed