Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 15/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 15/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 15/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 15/20 | 0.48 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.44 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.44 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5767296 | 0.81 | PDK1 (0.47) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7835701 | 0.79 | PDK1 (0.48) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL5766421 | 0.78 | PDK1 (0.48) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7833602 | 0.73 | PDK1 (0.53) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7833676 | 0.73 | MAPK14 (0.52) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL5766444 | 0.73 | KDM4E (0.46) | CA12CA9CA1CA2HSD17B3 | |
| SCHEMBL7833134 | 0.73 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL5764585 | 0.72 | PDK1 (0.44) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL5766316 | 0.72 | PDK1 (0.44) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL5764100 | 0.72 | PDK1 (0.44) | PDK1PDK2PDK3PDK4ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |