Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 14/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 5/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 5/20 | 0.38 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.38 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL603549 | 0.87 | CARM1 (0.53) | DRD4SIGMAR1TMEM97DRD3CARM1 | |
| SCHEMBL603848 | 0.87 | DRD4 (0.46) | DRD4SIGMAR1TMEM97DRD3CARM1 | |
| SCHEMBL603140 | 0.87 | CARM1 (0.53) | DRD4SIGMAR1TMEM97DRD3CARM1 | |
| SCHEMBL605127 | 0.84 | KDM4E (0.49) | DRD4SIGMAR1TMEM97DRD3 | |
| SCHEMBL606084 | 0.83 | ACHE (0.51) | DRD4SIGMAR1TMEM97DRD3 | |
| SCHEMBL604137 | 0.81 | SIGMAR1 (0.64) | DRD4SIGMAR1TMEM97DRD3 | |
| SCHEMBL604428 | 0.81 | DRD2 (0.46) | SIGMAR1 | |
| SCHEMBL605914 | 0.81 | DRD2 (0.46) | — | |
| SCHEMBL605047 | 0.81 | SIGMAR1 (0.44) | DRD4SIGMAR1TMEM97DRD3CARM1 | |
| SCHEMBL606957 | 0.81 | CARM1 (0.50) | DRD4SIGMAR1TMEM97DRD3CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651634-A1 | IMIDAZOL DERIVATIVES OF PIPERIDINE AS HISTAMINE ANTAGONISTS | AstraZeneca AB (SE) | 2006-05-03 | — | — | EP | claimed |
| WO-2005014579-A1 | IMIDAZOL DERIVATIVES OF PIPERDINE AS HISTAMINE ANTAGONISTS | ASTRAZENECA AB (SE) | 2005-02-17 | — | — | WO | claimed |