Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765522 | 1.00 | MCHR1 (0.45) | MCHR1CYP2D6OPRM1CHRM2CHRM3 | |
| SCHEMBL6150897 | 0.75 | MEN1 (0.44) | CHRM2CHRM3MEN1KMT2AUTS2R | |
| SCHEMBL6151344 | 0.75 | MEN1 (0.44) | CHRM2CHRM3MEN1KMT2AUTS2R | |
| SCHEMBL6150894 | 0.72 | MEN1 (0.52) | CYP2D6OPRM1CHRM2CHRM3MEN1 | |
| SCHEMBL5366572 | 0.72 | SLC6A2 (0.57) | CYP2D6OPRM1CHRM2CHRM3MEN1 | |
| SCHEMBL2112619 | 0.71 | HSD17B2 (0.50) | MEN1KMT2ANR3C2MAPK1 | |
| SCHEMBL29275128 | 0.70 | TRPM8 (0.58) | CYP2D6CHRM2CHRM3MEN1KMT2A | |
| SCHEMBL5366665 | 0.69 | MEN1 (0.76) | CYP2D6OPRM1CHRM2CHRM3MEN1 | |
| SCHEMBL28758536 | 0.69 | SLC6A2 (0.46) | OPRM1CHRM2CHRM3MEN1KMT2A | |
| SCHEMBL28758537 | 0.69 | SLC6A2 (0.46) | OPRM1CHRM2CHRM3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594840-B1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-09-27 | — | — | EP | disclosed |