Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.36 |
| ▸ | SRC | P12931 | 5/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | LATS1 | O95835 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766984 | 1.00 | NTRK1 (0.38) | NTRK1FLT3KDRFGFR1SRC | |
| SCHEMBL5765955 | 0.95 | LTA4H (0.36) | NTRK1FLT3KDRFGFR1SRC | |
| SCHEMBL5768958 | 0.90 | LTA4H (0.39) | NTRK1FLT3KDRFGFR1IRAK4 | |
| SCHEMBL5767363 | 0.90 | LTA4H (0.39) | NTRK1FLT3KDRFGFR1IRAK4 | |
| SCHEMBL5764733 | 0.89 | KDR (0.45) | NTRK1FLT3KDRFGFR1SRC | |
| SCHEMBL5767666 | 0.87 | CHKA (0.41) | NTRK1FLT3KDRFGFR1SRC | |
| SCHEMBL5767801 | 0.87 | NTRK1 (0.44) | NTRK1FLT3KDRFGFR1SRC | |
| SCHEMBL5764607 | 0.87 | FGFR1 (0.47) | KDRFGFR1SRC | |
| SCHEMBL5767092 | 0.86 | IRAK4 (0.40) | NTRK1FLT3FGFR1SRCS1PR1 | |
| SCHEMBL5765588 | 0.86 | IRAK4 (0.40) | NTRK1FLT3FGFR1SRCS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235825-B1 | NOVEL BENZOIMIDAZOLE DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | PFIZER PROD INC (US) | 2006-01-25 | — | — | EP | claimed |