Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766110 | 0.88 | MAPK14 (0.47) | MAPK14MAPK13KDM4EALDH1A1NOTUM | |
| SCHEMBL4823102 | 0.78 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL3094110 | 0.73 | MAPK14 (0.48) | MAPK14METKDM4EALDH1A1 | |
| SCHEMBL20579237 | 0.73 | MAPK14 (0.61) | MAPK14MAPK13 | |
| SCHEMBL23959346 | 0.72 | KDM4E (0.65) | MAPK14KDM4EALDH1A1 | |
| SCHEMBL5766791 | 0.72 | MAPK14 (0.47) | MAPK14KDM4E | |
| SCHEMBL5765239 | 0.71 | MAPK14 (0.53) | MAPK14MAPK13NOTUM | |
| SCHEMBL5765801 | 0.68 | MAPK14 (0.39) | MAPK14 | |
| SCHEMBL5765799 | 0.67 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL5764736 | 0.67 | HSD11B1 (0.44) | MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |