Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765684 | 0.87 | MAPK14 (0.49) | MAPK14MAPK13HPGDNOTUM | |
| SCHEMBL13687352 | 0.82 | MAPK14 (0.58) | MAPK14MAPK13SCN5AHPGD | |
| SCHEMBL11488779 | 0.80 | MAPK14 (0.67) | MAPK14SCN5AHPGD | |
| SCHEMBL5765074 | 0.77 | MAPK14 (0.72) | MAPK14MAPK13 | |
| SCHEMBL5765754 | 0.71 | MAPK14 (0.43) | MAPK14MAPK13NOTUM | |
| SCHEMBL16686975 | 0.71 | MAPK14 (0.47) | MAPK14SCN5A | |
| SCHEMBL5766110 | 0.70 | MAPK14 (0.47) | MAPK14MAPK13MEN1HPGDKMT2A | |
| SCHEMBL5773810 | 0.70 | MAPK14 (1.00) | MAPK14 | |
| SCHEMBL13687351 | 0.69 | POLB (0.46) | MAPK14 | |
| SCHEMBL13687337 | 0.69 | SCN5A (0.50) | MAPK14SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |