Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | TP53 | P04637 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1543659 | 0.87 | KMT2A (0.47) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1543965 | 0.86 | ALDH1A1 (0.69) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1543793 | 0.86 | SMN1; SMN2 (0.69) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1543769 | 0.79 | MAPT (0.50) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1544317 | 0.78 | SMN1; SMN2 (0.68) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1543922 | 0.78 | MAPT (0.76) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1544022 | 0.77 | MAPT (0.68) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5758372 | 0.75 | OPRK1 (0.49) | TP53KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1544035 | 0.73 | MAPT (0.52) | MAPTTP53KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1544241 | 0.71 | KMT2A (0.56) | TP53KMT2AMEN1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723144-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006014185-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | WO | disclosed |