Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.66 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.66 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.66 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.66 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.66 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522799 | 0.82 | GABRG2 (0.60) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL341479 | 0.80 | GABRG2 (0.65) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| Mk-0777 SCHEMBL1042961 | 0.80 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| Mk-0777 SCHEMBL29469728 | 0.80 | GABRG2 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2662027 | 0.79 | GABRG2 (0.64) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2662134 | 0.79 | GABRG2 (0.66) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2654371 | 0.78 | GABRG2 (0.65) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658340 | 0.78 | GABRG2 (0.65) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL12794146 | 0.76 | GABRG2 (0.73) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL12794104 | 0.76 | GABRG2 (0.71) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430055-B1 | 7-TERT-BUTYL-3-(2-FLUOROPHENYL)-6-(2H-¬1,2,4|TRIAZOL-3-YLMETHOXY)-¬1,2,4|TRIAZOLO¬4,3-B|PYRIDAZINE FOR THE TREATMENT OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME (GB) | 2006-07-12 | — | — | EP | claimed |
| US-7015224-B2 | 7-Tert-butyl-3-(2-fluorophenyl)-6-(2H-(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo (4,3b) pyridazine for the treatment of anxiety and convulsions | MERCK SHARP & DOHME LTD. | 2006-03-21 | — | — | US | claimed |
| US-20040242586-A1 | 7-Tert-butyl-3-(2-fluoropenyl)-6-(2h(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo 4,3b)pyridazine for the treatment of anxiety and convulsions | MERCK SHARP & DOHME LTD. (GB) | 2004-12-02 | — | — | US | claimed |
| EP-1430055-B1 | 7-TERT-BUTYL-3-(2-FLUOROPHENYL)-6-(2H-¬1,2,4|TRIAZOL-3-YLMETHOXY)-¬1,2,4|TRIAZOLO¬4,3-B|PYRIDAZINE FOR THE TREATMENT OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME (GB) | 2006-07-12 | — | — | EP | disclosed |
| US-7015224-B2 | 7-Tert-butyl-3-(2-fluorophenyl)-6-(2H-(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo (4,3b) pyridazine for the treatment of anxiety and convulsions | MERCK SHARP & DOHME LTD. | 2006-03-21 | — | — | US | disclosed |
| US-20040242586-A1 | 7-Tert-butyl-3-(2-fluoropenyl)-6-(2h(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo 4,3b)pyridazine for the treatment of anxiety and convulsions | MERCK SHARP & DOHME LTD. (GB) | 2004-12-02 | — | — | US | disclosed |
| EP-1430055-A1 | 7-TERT-BUTYL-3-(2-FLUOROPHENYL)-6-(2H-[1,2,4]TRIAZOL-3-YLMETHOXY)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE FOR THE TREATMENT OF ANXIETY AND CONVULSIONS | MERCK SHARP & DOHME LTD. (GB) | 2004-06-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242586-A1 | 7-Tert-butyl-3-(2-fluoropenyl)-6-(2h(1,2,4)triazol-3-ylmethoxy)-(1,2,4)triazolo 4,3b)pyridazine for the treatment of anxiety and convulsions | GABRA3, GABRA4, GABBR1 | GABRG2 13/4885GABRB3 6/4885GABRA3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.