Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5457042 | 0.88 | KDR (0.36) | KDRRAF1BRAFPDE10ACSNK1A1 | |
| SCHEMBL5450929 | 0.85 | — | — | |
| SCHEMBL5454087 | 0.82 | RAF1 (0.33) | KDRRAF1BRAFPDE10ACSNK1A1 | |
| SCHEMBL5453176 | 0.81 | RIPK1 (0.38) | KDRRAF1BRAFPDE10ACSNK1A1 | |
| SCHEMBL14521447 | 0.73 | POLB (0.41) | KDR | |
| SCHEMBL5459692 | 0.72 | KDR (0.31) | KDR | |
| SCHEMBL5448421 | 0.71 | TEK (0.37) | KDRTEK | |
| SCHEMBL5456884 | 0.71 | NPC1 (0.46) | KDRRAF1BRAFTEK | |
| SCHEMBL5450095 | 0.70 | KDR (0.44) | KDRRAF1BRAFPDE10ACSNK1A1 | |
| SCHEMBL5452232 | 0.69 | TEK (0.30) | KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656377-A1 | AMINOBENZIMIDAZOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-05-17 | — | — | EP | claimed |
| WO-2005019216-A1 | AMINOBENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-03-03 | — | — | WO | claimed |