SCHEMBL5767136

SCHEMBL5767136

O=C(O)C(OC1(c2cccc3c2oc2ccccc23)C=CC(c2ccccc2)=CC1F)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.33
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5764068 0.71 PTPN1 (0.33) PTPN1
SCHEMBL5766783 0.71 KDM4E (0.33) PTPN1MAPT
SCHEMBL5765164 0.71 PTPN1 (0.32) PTPN1
SCHEMBL5767369 0.64 MMP12 (0.36) MAPT
SCHEMBL5741189 0.62 NPSR1 (0.31) MAPT
SCHEMBL4265420 0.62 PTPN1 (0.59) PTPN1
SCHEMBL27619437 0.60 THRB (0.33)
SCHEMBL4275296 0.59 PPARG (0.50) PTPN1MAPT
SCHEMBL29430961 0.57 ALOX5 (0.36) MAPT
SCHEMBL29209271 0.57 HSD17B10 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2006525329-A 2006-11-09 JP claimed
EP-1620420-A2 SUBSTITUTED CARBOXYLIC ACIDS The Institutes for Pharmaceutical Discovery, LLC (US) 2006-02-01 EP claimed
WO-2004099168-A2 SUBSTITUTED CARBOXYLIC ACIDS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO claimed
EP-1620420-A2 SUBSTITUTED CARBOXYLIC ACIDS The Institutes for Pharmaceutical Discovery, LLC (US) 2006-02-01 EP disclosed
WO-2004099168-A2 SUBSTITUTED CARBOXYLIC ACIDS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO disclosed