Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770204 | 0.85 | CTSK (0.44) | CTSKPOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1219526 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL12896154 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL1220239 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL13038043 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL12884069 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL1221071 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL1219529 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL14393674 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL12884095 | 0.82 | GPR119 (0.47) | NPC1RAB9AALDH1A1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656345-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005021500-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |