Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 12/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 3/20 | 0.40 |
| ▸ | DDO | Q99489 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769848 | 0.83 | DAO (0.50) | RHEBIMPDH2IMPDH1IDO1DAO | |
| SCHEMBL28352953 | 0.83 | IMPDH2 (0.43) | RHEBIMPDH2IMPDH1IDO1DAO | |
| SCHEMBL8088130 | 0.80 | CTSV (0.44) | IMPDH2IMPDH1IDO1DAODDO | |
| SCHEMBL30120739 | 0.80 | HTR2C (0.45) | IMPDH2IMPDH1IDO1DAODDO | |
| SCHEMBL23706115 | 0.79 | RHEB (0.55) | RHEBHRH4 | |
| SCHEMBL4561870 | 0.79 | RHEB (0.57) | RHEBDAOHRH4 | |
| SCHEMBL11719429 | 0.79 | DAO (0.53) | RHEBDAODDOALDH1A1 | |
| SCHEMBL30096998 | 0.79 | RHEB (0.55) | RHEBHRH4 | |
| SCHEMBL9534359 | 0.79 | KDM4E (0.46) | IMPDH2IMPDH1IDO1DAODDO | |
| SCHEMBL9587971 | 0.79 | ASH1L (0.44) | RHEBIMPDH2IMPDH1IDO1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509515-A4 | SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2006-07-05 | — | — | EP | disclosed |
| EP-1509515-A2 | SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003097806-A2 | SUBSTITUTED 4-ARYL-4H-PYRROLO[2,3-H]CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2003-11-27 | — | — | WO | disclosed |